Article
Transcription activation by Escherichia coli FNR protein: similarities to, and differences from, the CRP paradigm.
Nucleic acids research - 1 May 1998
Li B, Wing H, Lee D, Wu H C, Busby S
Abstract excerpt
During transcription activation at FNR-dependent promoters where the DNA site for FNR overlaps the -35 element, a surface-exposed activating region in the upstream subunit of the FNR dimer interacts with the C-terminal domain of the RNA polymerase alpha subunit. Starting with a cloned fnr gene encoding a defective FNR derivative carrying substitutions in this activating region, we screened a library of random...
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