Article
In vivo and in vitro mutants of FNR the anaerobic transcriptional regulator of E. coli.
FEBS letters - 17 Sept 1990
Sharrocks A D, Green J, Guest J R
Abstract excerpt
FNR regulates the expression of target genes in response to anaerobiosis. It resembles the catabolite gene activator or cAMP-receptor protein (CRP) except for the presence of an N-terminal cysteine cluster, which may form a redox-sensing iron-binding site. Site-directed mutagenesis has shown that 3 of the 4 cysteine residues in the N-terminal cluster (Cys-20, -23 and -29, but not Cys-16) and the only other...
Topics
- Amino Acid Sequence
- Anaerobiosis
- Bacterial Proteins
- Base Sequence
- Chromosome Deletion
- Cysteine
- DNA-Binding Proteins
- Escherichia coli
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed