Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population.

doi:10.1007/s12253-017-0267-6

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Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population.

Pathology oncology research : POR - 1 Jul 2018

López-Cortés Andrés, Cabrera-Andrade Alejandro, Oña-Cisneros Fabián, Echeverría Carolina, Rosales Felipe, Ortiz Malena, Tejera Eduardo, Paz-Y-Miño César

Abstract excerpt

Breast cancer (BC) is the leading cause of cancer related death among women in 2014. The AURKA gene that encodes the protein called Aurora kinase A plays an important role in the progression of the cell cycle, by controlling and promoting the entry into the phase of mitosis. The single nucleotide polymorphism AURKA T91A (rs2273535) (Phe21Ile) has been identified as functional alternator of this kinase, the Ile...

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PMID: 28647900
DOI: 10.1007/s12253-017-0267-6

Genes

AURKA

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rs2273535

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