Article
Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations.
Cancer letters - 8 Jun 2007
Vidarsdottir Linda, Bodvarsdottir Sigridur K, Hilmarsdottir Holmfridur, Tryggvadottir Laufey, Eyfjord Jorunn E
Abstract excerpt
In this study 759 breast cancer patients, including 9 BRCA1 and 98 BRCA2 mutation carriers, and 653 mutation-negative unaffected controls were genotyped for the AURKA 91T -->A polymorphism. Individuals homozygous for the 91A allele were found to be at increased risk of breast cancer compared to 91T homozygotes (OR=1.87; 95% CI=1.09-3.21). This association was strengthened when cases carrying BRCA mutations were...
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