Article
Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast.
Current biology : CB - 5 Mar 2002
Toyoda Yusuke, Furuya Kanji, Goshima Gohta, Nagao Koji, Takahashi Kohta, Yanagida Mitsuhiro
Abstract excerpt
BACKGROUND: Proteins conserved from yeast to human hold two sister chromatids together. The failure to form cohesion in the S phase results in premature separation of chromatids in G2/M. Mitotic kinetochores free from microtubules or the lack of tension are known to activate spindle checkpoint. RESULTS: The loss of chromatid cohesion in fission yeast mutants (mis4-242 and rad21-K1) leads to the activation of...
Topics
- Cell Cycle
- Cell Cycle Proteins
- Chromatids
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Green Fluorescent Proteins
- Kinetochores
- Luminescent Proteins
- Mutation
- Nuclear Proteins
- Phosphoproteins
- Recombinant Fusion Proteins
- Schizosaccharomyces