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Article

Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast.

Current biology : CB - 5 Mar 2002

Toyoda Yusuke, Furuya Kanji, Goshima Gohta, Nagao Koji, Takahashi Kohta, Yanagida Mitsuhiro

Abstract excerpt

BACKGROUND: Proteins conserved from yeast to human hold two sister chromatids together. The failure to form cohesion in the S phase results in premature separation of chromatids in G2/M. Mitotic kinetochores free from microtubules or the lack of tension are known to activate spindle checkpoint. RESULTS: The loss of chromatid cohesion in fission yeast mutants (mis4-242 and rad21-K1) leads to the activation of...

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PMID: 11882285
DOI: 10.1016/s0960-9822(02)00692-9

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Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast.PMID 11882285Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

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Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair.Semantic proximity Read ↗

Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells.Semantic proximity Read ↗

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