Article
Association analysis of GRK3 gene promoter variants in cocaine abuse.
Psychiatric genetics - 1 Aug 2007
Guindalini Camila, Collier David, Laranjeira Ronaldo, Barrett Tom B, Kelsoe John, Castelo Adauto, Vallada Homero, Breen Gerome
Abstract excerpt
The G protein-coupled receptor kinase 3 gene (GRK3) is a candidate gene for cocaine addiction because it is involved in the regulation of several neurotransmitter receptors, including the response to dopaminergic agonists such as methamphetamine and cocaine. We hypothesized that genetic variants in the GRK3 gene might be associated with an increased risk of cocaine addiction. To test this, we genotyped three...
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