Article
A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample.
Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2006
Guindalini Camila, Howard Mark, Haddley Kate, Laranjeira Ronaldo, Collier David, Ammar Nik, Craig Ian, O'Gara Colin, Bubb Vivian J, Greenwood Tiffany, Kelsoe John, Asherson Phil, Murray Robin M, Castelo Adauto, Quinn John P, Vallada Homero, Breen Gerome
Abstract excerpt
The dopamine (DA) transporter DAT1 is a major target bound by cocaine in brain. We examined the influence of functional genetic variants in DAT1 on cocaine addiction. Repeat polymorphisms, including a 30-bp variable-number tandem repeat (VNTR) in intron 8 (Int8 VNTR) with two common alleles, were genotyped in cocaine-dependent abusers (n = 699) and in controls with no past history of drug abuse (n = 866) from São...
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