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Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease.

Pharmacogenetics and genomics - 1 Sept 2005

Kelada Samir N, Costa-Mallen Paola, Checkoway Harvey, Carlson Christopher S, Weller Terri-Smith, Swanson Phillip D, Franklin Gary M, Longstreth W T, Afsharinejad Zahra, Costa Lucio G

Abstract excerpt

The dopamine transporter (DAT) plays a critical role in dopaminergic neurotransmission and is also the major site of action for some drugs of abuse. The coding region of the DAT gene, SLC6A3, is well conserved, but non-coding regions are more variable, most notably a variable number of tandem repeats (VNTR) polymorphism in the 3' untranslated region, which has been studied in a number of dopamine-related...

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PMID: 16041244
DOI: 10.1097/01.fpc.0000170917.04275.d6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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