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Article

Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression.

Biological psychiatry - 15 Jul 2008

Zhou Xianjin, Barrett Thomas B, Kelsoe John R

Abstract excerpt

BACKGROUND: We have previously reported a single nucleotide polymorphism (P-5, G-384A) in the proximal promoter of the gene for G protein receptor kinase 3 (GRK3) that was associated with bipolar disorder in two independent samples. In this study, we examined whether the G-384A variant has a functional effect on GRK3 transcription. METHODS: Electrophoretic mobility shift assays were conducted using nuclear...

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Identifiers

PMID: 18359007
DOI: 10.1016/j.biopsych.2007.12.017
PMCID: PMC6528791

Genes

GRK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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