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Article

The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2006

Bouez Charbel, Reynaud Caroline, Noblesse Emmanuelle, Thépot Amélie, Gleyzal Claudine, Kanitakis Jean, Perrier Eric, Damour Odile, Sommer Pascal

Abstract excerpt

Lysyl oxidase initiates the enzymatic stage of collagen and elastin cross-linking. Among five isoforms comprising the lysyl oxidase family, LOX is the better studied. LOX is associated to an antitumor activity in ras-transformed fibroblasts, and its expression is down-regulated in many carcinomas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16533769
DOI: 10.1158/1078-0432.CCR-05-1456

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16533769-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model.PMID 16533769Read ↗

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