The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.

doi:10.1074/jbc.M406639200

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Article

The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.

The Journal of biological chemistry - 24 Sept 2004

Palamakumbura Amitha H, Jeay Sébastien, Guo Ying, Pischon Nicole, Sommer Pascal, Sonenshein Gail E, Trackman Philip C

Abstract excerpt

Lysyl oxidase is an extracellular enzyme critical for the normal biosynthesis of collagens and elastin. In addition, lysyl oxidase reverts ras-mediated transformation, and lysyl oxidase expression is down-regulated in human cancers. Since suramin inhibits growth factor signaling pathways and induces lysyl oxidase in ras-transformed NIH3T3 cells (RS485 cells), we sought to investigate the effects of suramin on the...

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PMID: 15277520
DOI: 10.1074/jbc.M406639200

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The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.PMID 15277520Read ↗

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