Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells

9 Oct 2014

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, but little is known about the role of the c-Rel subunit in solid cancer and PDAC apoptosis control....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Liver physiology and pathology
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25299780
DOI: 10.1038/cddis.2014.417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cellsPMID 25299780Read ↗

NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancerSemantic proximity Read ↗

TNFR2 mediates pancreatic cancer proliferation, migration, and invasion via the NF‑κB signaling pathwaySemantic proximity Read ↗

The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancerSemantic proximity Read ↗

TRAIL/NF-κB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell LinesSemantic proximity Read ↗

RelB Upregulates PD-L1 and Exacerbates Prostate Cancer Immune EvasionSemantic proximity Read ↗

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cellsSemantic proximity Read ↗

NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancerSemantic proximity Read ↗

Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1.Semantic proximity Read ↗

Subunit-Specific Role of NF-κB in CancerSemantic proximity Read ↗

A Key Role for NF-<i>κ</i>B Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector FunctionsSemantic proximity Read ↗

Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.Semantic proximity Read ↗

IL20RB promotes pancreatic cancer progression by activating NF- kB signalling and promoting EMTSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.