Article
NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function.
Nature cell biology - 1 Nov 2002
Wang Yongqing, Cui Hongjuan, Schroering Allen, Ding Jane L, Lane William S, McGill Gaël, Fisher David E, Ding Han-Fei
Abstract excerpt
Nuclear factor-kappa B (NF-kappa B) promotes cell survival by upregulating expression of anti-apoptotic genes, a process that is antagonized by inhibitors of kappa B (I kappa B) factors. The only NF-kappa B family member known to be mutated in human cancer is NF-kappa B2 p100 (ref. 2), a factor with I kappa B activity. Here, we report the isolation from irradiated mouse tumour cells of a complex that induces...
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