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Article

Lysyl oxidases: linking structures and immunity in the tumor microenvironment

25 Oct 2019

Abstract excerpt

The lysyl oxidases (LOXs) are a family of enzymes deputed to cross-link collagen and elastin, shaping the structure and strength of the extracellular matrix (ECM). However, many novel "non-canonical" functions, alternative substrates, and regulatory mechanisms have been described and are being continuously elucidated. The activity of LOXs, therefore, appears to be integrated into a complex network of signals...

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PMID: 31650200
DOI: 10.1007/s00262-019-02404-x

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