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Article

Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration.

The Journal of biological chemistry - 25 Dec 1991

Sherley J L

Abstract excerpt

As an approach to defining the role of p53 in cellular proliferation, murine cell lines were derived which contain a stably transfected temperature-inducible p53 expression system. Cell lines derived with the system exhibited a 3-6-fold physiologic elevation in the cellular p53 concentration when grown at 32.5 degrees C. A p53 induction phenotype was defined by examination of the growth properties of these lines...

Topics

Animals
Cell Line
Guanine Nucleotides
Inosine Monophosphate
Kinetics
Mice
Phenotype
Plasmids
Precipitin Tests
Purine Nucleotides
Signal Transduction
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 1761576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1761576-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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