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Article

p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance.

Molecular and cellular biology - 1 Jul 2004

Razak Zaineb R Abdul, Varkonyi Robert J, Kulp-McEliece Michelle, Caslini Corrado, Testa Joseph R, Murphy Maureen E, Broccoli Dominique

Abstract excerpt

Telomere stabilization is critical for tumorigenesis. A number of tumors and cell lines use a recombination-based mechanism, alternative lengthening of telomeres (ALT), to maintain telomere repeat arrays. Current data suggest that the mutation of p53 facilitates the activation of this pathway. In addition to its functions in response to DNA damage, p53 also acts to suppress recombination, independent of...

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Identifiers

PMID: 15199150
DOI: 10.1128/MCB.24.13.5967-5977.2004
PMCID: PMC480899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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