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Article

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.

Nature communications - 12 Jun 2015

Kollareddy Madhusudhan, Dimitrova Elizabeth, Vallabhaneni Krishna C, Chan Adriano, Le Thuc, Chauhan Krishna M, Carrero Zunamys I, Ramakrishnan Gopalakrishnan, Watabe Kounosuke, Haupt Ygal, Haupt Sue, Pochampally Radhika, Boss Gerard R, Romero Damian G, Radu Caius G, Martinez Luis A

Abstract excerpt

Mutant p53 (mtp53) is an oncogene that drives cancer cell proliferation. Here we report that mtp53 associates with the promoters of numerous nucleotide metabolism genes (NMG). Mtp53 knockdown reduces NMG expression and substantially depletes nucleotide pools, which attenuates GTP-dependent protein activity and cell invasion. Addition of exogenous guanosine or GTP restores the invasiveness of mtp53 knockdown...

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Identifiers

PMID: 26067754
DOI: 10.1038/ncomms8389
PMCID: PMC4467467

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Source receipt: pubmed, retrieved 7 Sept 2026.

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