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Article

Regulation of a eukaryotic gene by GTP-dependent start site selection and transcription attenuation.

Molecular cell - 25 Jul 2008

Kuehner Jason N, Brow David A

Abstract excerpt

Guanine nucleotide negatively regulates yeast inosine monophosphate dehydrogenase (IMPDH) mRNA synthesis by an unknown mechanism. IMPDH catalyzes the first dedicated step of GTP biosynthesis, and feedback control of its expression maintains the proper balance of purine nucleotides. Here we show that RNA polymerase II (Pol II) responds to GTP concentration. When GTP is sufficient, Pol II initiates transcription of...

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Identifiers

PMID: 18657503
DOI: 10.1016/j.molcel.2008.05.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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