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Article

The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells.

Oncogene - 17 Oct 1996

Peled A, Schwartz D, Elkind N B, Wolkowicz R, Li R, Rotter V

Abstract excerpt

p53 was shown to play a central role in the maintenance of genomic integrity. The present experiments suggest that p53 is involved in the control of cell ploidity. Using a p53 non-producer cell line, M1/2, that was reconstituted to express either wild type or mutant p53 protein, by infection with the temperature sensitive (Ts) p53Val135 virus, it was found that both loss of wild type p53 or overexpression of...

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PMID: 8895513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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