Article
The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells.
Oncogene - 17 Oct 1996
Peled A, Schwartz D, Elkind N B, Wolkowicz R, Li R, Rotter V
Abstract excerpt
p53 was shown to play a central role in the maintenance of genomic integrity. The present experiments suggest that p53 is involved in the control of cell ploidity. Using a p53 non-producer cell line, M1/2, that was reconstituted to express either wild type or mutant p53 protein, by infection with...
Topics
- Animals
- Clone Cells
- DNA, Neoplasm
- Gamma Rays
- Leukemia, Myelomonocytic, Acute
- Mice
- Mutation
- Ploidies
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53