Article
Inactivation of p53 in normal human cells increases G2/M arrest and sensitivity to DNA-damaging agents.
International journal of cancer - 30 Jan 1998
Céraline J, Deplanque G, Duclos B, Limacher J M, Hajri A, Noel F, Orvain C, Frébourg T, Klein-Soyer C, Bergerat J P
Abstract excerpt
p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we show that cisplatin and UV radiation induce G2/M arrest which is temporally linked to p53-protein induction. To study...
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