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Article

A Defect in the p53 Response Pathway Induced by de Novo Purine Synthesis Inhibition

26 Nov 2003

Abstract excerpt

p53 is believed to sense cellular ribonucleotide depletion in the absence of DNA strand breaks and to respond by imposition of a p21-dependent G1 cell cycle arrest. We now report that the p53-dependent G1 checkpoint is blocked in human carcinoma cell lines after inhibition of de novo purine synthesis by folate analogs inhibitory to glycinamide ribonucleotide formyltransferase (GART). p53 accumulated in HCT116,...

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Identifiers

PMID: 14517211
DOI: 10.1074/jbc.m304844200

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