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Article

No association between low density lipoprotein receptor genetic variants and Alzheimer's disease risk.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2006

Rodríguez Eloy, Mateo Ignacio, Llorca Javier, Sánchez-Quintana Coro, Infante Jon, Berciano José, Combarros Onofre

Abstract excerpt

A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (APOE) epsilon4 allele is a risk factor for sporadic AD raises the possibility that the receptors to which APOE binds on the surface of neurons are also involved in the neurodegenerative process. To...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16741934
DOI: 10.1002/ajmg.b.30341

Genes

APOE
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between low density lipoprotein receptor genetic variants and Alzheimer's disease risk.PMID 16741934Read ↗

No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample.Semantic proximity Read ↗

No association of genetic variants of liver X receptor-beta with Alzheimer's disease risk.Semantic proximity Read ↗

Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.Semantic proximity Read ↗

No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.Semantic proximity Read ↗

Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease.Semantic proximity Read ↗

Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.Semantic proximity Read ↗

No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples.Semantic proximity Read ↗

Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population.Semantic proximity Read ↗

Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease.Semantic proximity Read ↗

The very low density lipoprotein (VLDL) receptor is a genetic susceptibility factor for Alzheimer disease in a European Caucasian population.Semantic proximity Read ↗

Risk of Alzheimer's disease is associated with a very low-density lipoprotein receptor genotype in Northern Ireland.Semantic proximity Read ↗

The very high prevalence of AD in an Arab population is not explained by APOE epsilon4 allele frequency.Semantic proximity Read ↗

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