Article
Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease.
American journal of medical genetics - 8 Jan 2001
Sánchez L, Alvarez V, González P, González I, Alvarez R, Coto E
Abstract excerpt
The LRP-associated protein is involved in the amount of mature LRP expressed on liver and brain. LRP is the main ApoE receptor and also binds alpha2-macroglobulin (alpha2M), a protein that associates with the beta-amyloid protein (betaA). By binding to alpha2M, LRP is responsible for the clearance of secreted betaA, thus preventing fibril formation. Genetic variation at the APOE, A2M, and LRP genes has been...
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