Article
Treatment of uninformative families in mean allele sharing tests for linkage.
Statistical applications in genetics and molecular biology - 1 Jan 2006
Mukhopadhyay Indranil, Feingold Eleanor, Wang Tao, Elston Robert C, Weeks Daniel E
Abstract excerpt
Using affected sibling pairs, the mean allele sharing statistic tests for linkage by testing if the mean proportion of alleles that are identical-by-descent (IBD) is equal to a half. The behavior of some versions of the mean allele sharing test statistic depends on whether or not families that are uninformative for their IBD status are included; the SIBPAL version provides less significant values when all...
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