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Article

Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL.

Biochemical and biophysical research communications - 22 Oct 2011

Hirano Hidemi, Matsuura Yoshiyuki

Abstract excerpt

The coordination of cytoskeletal actin dynamics with gene expression reprogramming is emerging as a crucial mechanism to control diverse cellular processes, including cell migration, differentiation and neuronal circuit assembly. The actin-binding transcriptional coactivator MAL (also known as MRTF-A/MKL1/BSAC) senses G-actin concentration and transduces Rho GTPase signals to serum response factor (SRF). MAL...

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Source

Identifiers

PMID: 21964294
DOI: 10.1016/j.bbrc.2011.09.079

Genes

MAL
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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