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Article

14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity.

Journal of cell science - 1 May 2005

Béguin Pascal, Mahalakshmi Ramasubbu N, Nagashima Kazuaki, Cher Damian H K, Takahashi Akira, Yamada Yuichiro, Seino Yutaka, Hunziker Walter

Abstract excerpt

Individual members of the RGK family of Ras-related GTPases, which comprise Rad, Gem/Kir, Rem and Rem2, have been implicated in important functions such as the regulation of voltage-gated calcium channel activity and remodeling of cell shape. The GTPase Kir/Gem inhibits the activity of calcium channels by interacting with the beta-subunit and also regulates cytoskeleton dynamics by inhibiting the Rho-Rho kinase...

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PMID: 15860732
DOI: 10.1242/jcs.02321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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