Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles.

Journal of cell science - 1 Aug 2002

Laporte Jocelyn, Blondeau Francois, Gansmuller Anne, Lutz Yves, Vonesch Jean-Luc, Mandel Jean-Louis

Abstract excerpt

Myotubularin, the phosphatase mutated in X-linked myotubular myopathy, was shown to dephosphorylate phosphatidylinositol 3-monophosphate (PtdIns3P) and was also reported to interact with nuclear transcriptional regulators from the trithorax family. We have characterized a panel of specific antibodies and investigated the subcellular localization of myotubularin. Myotubularin is not detected in the nucleus, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Compartmentation
Share to Cell Surface Extensions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasmic Vesicles

Share to Eukaryotic Cells

Share to Myopathies, Structural, Congenital

Share to Phosphatidylinositol Phosphates

Share to Protein Tyrosine Phosphatases, Non-Receptor

Share to rac1 GTP-Binding Protein

Source

Identifiers

PMID: 12118066
DOI: 10.1242/jcs.115.15.3105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles.PMID 12118066Read ↗

Functional redundancy in the myotubularin family.Semantic proximity Read ↗

The myotubularin family: novel phosphoinositide regulators.Semantic proximity Read ↗

Interplay between myotubularins and Ca2+ homeostasis.Semantic proximity Read ↗

The myotubularin family: from genetic disease to phosphoinositide metabolism.Semantic proximity Read ↗

Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy.Semantic proximity Read ↗

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.Semantic proximity Read ↗

The structure and regulation of myotubularin phosphatases.Semantic proximity Read ↗

Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3.Semantic proximity Read ↗

Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.Semantic proximity Read ↗

Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish.Semantic proximity Read ↗

Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23.Semantic proximity Read ↗

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.