Article
Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype.
Cells - 11 Mar 2021
Kant Theresa A, Newe Manja, Winter Luise, Hoffmann Maximilian, Kämmerer Susanne, Klapproth Erik, Künzel Karolina, Kühnel Mark P, Neubert Lavinia, El-Armouche Ali, Künzel Stephan R
Abstract excerpt
Pulmonary fibrosis is the chronic-progressive replacement of healthy lung tissue by extracellular matrix, leading to the destruction of the alveolar architecture and ultimately death. Due to limited pathophysiological knowledge, causal therapies are still missing and consequently the prognosis is poor. Thus, there is an urgent clinical need for models to derive effective therapies. Polo-like kinase 2 (PLK2) is an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.