Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

Journal of cellular physiology - 1 Dec 2015

Carthy Jon M, Sundqvist Anders, Heldin Angelos, van Dam Hans, Kletsas Dimitris, Heldin Carl-Henrik, Moustakas Aristidis

Abstract excerpt

Transforming growth factor-β (TGF-β) is a multifunctional cytokine which stimulates the differentiation of fibroblasts into myofibroblasts. Myofibroblasts are critical for normal wound healing, but also accumulate pathologically in a number of chronic inflammatory conditions where they are key contributors to aberrant tissue remodeling and fibrosis, and in cancer stroma. In the current study, we identified a role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Cell Shape

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Myofibroblasts

Share to Tamoxifen

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 26096876
DOI: 10.1002/jcp.25049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.PMID 26096876Read ↗

TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders.Semantic proximity Read ↗

Fibroblast Growth Factor 2 as an Antifibrotic: Antagonism of Myofibroblast Differentiation and Suppression of Pro-Fibrotic Gene Expression.Semantic proximity Read ↗

MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype.Semantic proximity Read ↗

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.Semantic proximity Read ↗

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic InterventionSemantic proximity Read ↗

Rev-erbα agonists suppresses TGFβ1-induced fibroblast-to-myofibroblast transition and pro-fibrotic phenotype in human lung fibroblasts.Semantic proximity Read ↗

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.Semantic proximity Read ↗

Rac1 expression by fibroblasts is required for tissue repair in vivo.Semantic proximity Read ↗

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.Semantic proximity Read ↗

FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.Semantic proximity Read ↗

Elucidating the Cellular Mechanism for E2-induced Dermal FibrosisSemantic proximity Read ↗

ELL Protein-associated Factor 2 (EAF2) Inhibits Transforming Growth Factor β Signaling through a Direct Interaction with Smad3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.