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Article

Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis

15 Mar 2016

Abstract excerpt

Dysregulated repair of lung injury often results in lung fibrosis characterized by unremitting deposition of matrix components including glycosaminoglycan hyaluronan (HA). HA is mainly produced by hyaluronan synthases (HAS) in mesenchymal cells. We previously demonstrated that over-expression of HAS2 in mesenchymal cells in mice regulates the invasiveness of fibroblasts and promotes severe lung fibrosis. The...

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PMID: 26987798
DOI: 10.1016/j.matbio.2016.03.004

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