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Article

Lkb1 is required for TGFβ-mediated myofibroblast differentiation

8 Oct 2008

Abstract excerpt

Inactivating mutations of the tumor-suppressor kinase gene LKB1 underlie Peutz-Jeghers syndrome (PJS), which is characterized by gastrointestinal hamartomatous polyps with a prominent smooth-muscle and stromal component. Recently, it was noted that PJS-type polyps develop in mice in which Lkb1 deletion is restricted to SM22-expressing mesenchymal cells. Here, we investigated the stromal functions of Lkb1, which...

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Identifiers

PMID: 18840652
DOI: 10.1242/jcs.032706

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