Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis

29 May 2018

Abstract excerpt

mouse model. Notably, this function of MK2 was not mediated by its well-described immunomodulatory role in immune cells. Deletion of MK2 in intestinal mesenchymal cells (IMCs) led to both reduced tumor multiplicity and growth. Mechanistically, MK2 in IMCs was required for Hsp27 phosphorylation and the production of downstream tumorigenic effector molecules, dominantly affecting epithelial proliferation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29844172
DOI: 10.1073/pnas.1805683115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesisPMID 29844172Read ↗

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.Semantic proximity Read ↗

MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancerSemantic proximity Read ↗

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal nicheSemantic proximity Read ↗

<i>Map2k4</i> Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing Peroxisome Proliferator-Activated Receptor γ2 ExpressionSemantic proximity Read ↗

Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium.Semantic proximity Read ↗

Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer.Semantic proximity Read ↗

Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomasSemantic proximity Read ↗

MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer.Semantic proximity Read ↗

Distinct cellular functions of MK2.Semantic proximity Read ↗

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formationSemantic proximity Read ↗

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functionsSemantic proximity Read ↗

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.