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Article

Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.

The Journal of pathology - 1 Sept 2018

Koo Hyun Young, El-Baz Lamis Mf, House StaceyL, Cilvik Sarah N, Dorry Samuel J, Shoukry Nahla M, Salem Mohamed L, Hafez Hani S, Dulin Nickolai O, Ornitz David M, Guzy Robert D

Abstract excerpt

Fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of pulmonary fibrosis. Mice lacking FGF2 have increased mortality and impaired epithelial recovery after bleomycin exposure, supporting a protective or reparative function following lung injury. To determine whether FGF2 overexpression reduces bleomycin-induced injury, we developed an inducible genetic system to express FGF2 in type...

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Share to Alveolar Epithelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29873400
DOI: 10.1002/path.5106
PMCID: PMC6175645

Genes

FGF2
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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