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Article

Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis.

International journal of molecular sciences - 6 Feb 2018

Mikamo Masashi, Kitagawa Kyoko, Sakai Satoshi, Uchida Chiharu, Ohhata Tatsuya, Nishimoto Koji, Niida Hiroyuki, Suzuki Sayuri, Nakayama Keiichi I, Inui Naoki, Suda Takafumi, Kitagawa Masatoshi

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and no curative therapies. SCF-Skp2 E3 ligase is a target for cancer therapy, but there have been no reports about Skp2 as a target for IPF. Here we demonstrate that Skp2 is a promising therapeutic target for IPF. We examined whether disrupting Skp2 suppressed pulmonary fibrosis in a bleomycin (BLM)-induced mouse model and found that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29415439
DOI: 10.3390/ijms19020474
PMCID: PMC5855696

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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