Article
Diversity-generating retroelement homing regenerates target sequences for repeated rounds of codon rewriting and protein diversification.
Molecular cell - 26 Sept 2008
Guo Huatao, Tse Longping V, Barbalat Roman, Sivaamnuaiphorn Sameer, Xu Min, Doulatov Sergei, Miller Jeff F
Abstract excerpt
Diversity-generating retroelements (DGRs) introduce vast amounts of sequence diversity into target genes. During mutagenic homing, adenine residues are converted to random nucleotides in a unidirectional, reverse transcriptase-dependent transposition process from a donor template repeat (TR) to a recipient variable repeat (VR). Using a Bordetella bacteriophage DGR as a model, we demonstrate that homing occurs...
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