Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

26 Sept 2013

Abstract excerpt

Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. However, expressing an engineered HIV-1 long terminal repeat (LTR) site-specific recombinase (Tre), shown to excise integrated proviral DNA in vitro, may provide a novel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV Research and Treatment
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24086129
DOI: 10.1371/journal.ppat.1003587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized MicePMID 24086129Read ↗

Excision of HIV-1 Proviral DNA by Recombinant Cell Permeable Tre-RecombinaseSemantic proximity Read ↗

HIV-1 proviral DNA excision using an evolved recombinase.Semantic proximity Read ↗

Engineering T Cells to Functionally Cure HIV-1 InfectionSemantic proximity Read ↗

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificitySemantic proximity Read ↗

Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissueSemantic proximity Read ↗

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 DeficiencySemantic proximity Read ↗

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem CellsSemantic proximity Read ↗

Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease.Semantic proximity Read ↗

Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA.Semantic proximity Read ↗

Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined ImmunodeficiencySemantic proximity Read ↗

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized MiceSemantic proximity Read ↗

An engineered lox sequence containing part of a long terminal repeat of HIV-1 permits Cre recombinase-mediated DNA excision.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.