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Article

A Novel Yeast-Based Recombination Method to Clone and Propagate Diverse HIV-1 Isolates

1 May 2009

Abstract excerpt

Replication studies on human immunodeficiency virus 1 (HIV-1) rely on a few laboratory strains that are divergent from dominant HIV-1 subtypes in the epidemic. Several phenotypic differences between diverse HIV-1 isolates and subtypes could affect vaccine development and treatment, but this research field lacks robust cloning/virus production systems to study drug sensitivity, replication kinetics, or to develop...

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PMID: 19480640
DOI: 10.2144/000113119

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