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Article

Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA.

Nucleic acids research - 19 Sept 2017

Meinke Gretchen, Karpinski Janet, Buchholz Frank, Bohm Andrew

Abstract excerpt

As part of the HIV infection cycle, viral DNA inserts into the genome of host cells such that the integrated DNA encoding the viral proteins is flanked by long terminal repeat (LTR) regions from the retrovirus. In an effort to develop novel genome editing techniques that safely excise HIV provirus from cells, Tre, an engineered version of Cre recombinase, was designed to target a 34-bp sequence within the HIV-1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28934476
DOI: 10.1093/nar/gkx603
PMCID: PMC5766204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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