Article
Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study.
Investigative ophthalmology & visual science - 1 Jul 2007
de Jong Frank Jan, Ikram M Kamran, Despriet Dominiek D G, Uitterlinden André G, Hofman Albert, Breteler Monique M B, de Jong Paulus T V M
Abstract excerpt
PURPOSE: Retinal venular dilatation is associated with systemic inflammation. The hypothesis for the current study was that larger retinal venular diameters are related to the His allele of the Tyr402His polymorphism in the complement factor H (CFH) gene, a major inhibitor of the complement pathway. Possible effect modification by smoking and inflammatory markers was examined. METHODS: This cross-sectional study...
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