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Article

The Y402H variant of complement factor H is associated with age-related macular degeneration but not with diabetic retinal disease in the Go-DARTS study.

Diabetic medicine : a journal of the British Diabetic Association - 1 May 2009

Doney A S F, Leese G P, Olson J, Morris A D, Palmer C N A

Abstract excerpt

AIMS: The Y402H variant of complement factor H (CFH) is associated with risk of age-related macular degeneration (ARMD). In common with ARMD, diabetic retinal disease also appears to involve complement activation. The aim was to investigate the impact of Y402H on both retinal pathologies in patients with Type 2 diabetes (T2DM) undergoing systematic eye screening. METHODS: Patients with T2DM (n = 2350) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19646183
DOI: 10.1111/j.1464-5491.2009.02719.x

Genes

CFH

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Related research

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The Y402H variant of complement factor H is associated with age-related macular degeneration but not with diabetic retinal disease in the Go-DARTS study.PMID 19646183Read ↗

Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large.Semantic proximity Read ↗

Analysis of the Y402H variant of the complement factor H gene in age-related macular degeneration.Semantic proximity Read ↗

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in miceSemantic proximity Read ↗

Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration.Semantic proximity Read ↗

Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.Semantic proximity Read ↗

Complement factor H in AMD: Bridging genetic associations and pathobiology.Semantic proximity Read ↗

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.Semantic proximity Read ↗

Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular DegenerationSemantic proximity Read ↗

Complement factor H Y402H variant and risk of age-related macular degeneration in Asians: a systematic review and meta-analysis.Semantic proximity Read ↗

Association of the Complement Factor H Y402H Polymorphism and Response to Anti-Vascular Endothelial Growth Factor Treatment in Age-Related Macular Degeneration: An Updated Meta-Analysis.Semantic proximity Read ↗

Association of CFH Y402H polymorphism with both forms of advanced age-related macular degeneration in Turkish patients.Semantic proximity Read ↗

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