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Article

Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes.

Human molecular genetics - 1 Sept 2007

Thompson Cheryl L, Klein Barbara E K, Klein Ronald, Xu Zhiying, Capriotti Jennifer, Joshi Tripti, Leontiev Dmitry, Lee Kristine E, Elston Robert C, Iyengar Sudha K

Abstract excerpt

In this study, we investigated the associations of complement factor H (CFH) and hemicentin-1 (HMCN1) with age-related macular degeneration (AMD) and renal function. Three scales, measuring the course of AMD and drusen development, were examined in two samples: the Family Age-Related Macular degeneration Study (FARMS), consisting of families ascertained through a single individual with severe AMD, and an...

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Source

Identifiers

PMID: 17591627
DOI: 10.1093/hmg/ddm164

Genes

CFH
HMCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes.PMID 17591627Read ↗

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Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants.Semantic proximity Read ↗

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Can genetic associations change with age? CFH and age-related macular degeneration.Semantic proximity Read ↗

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Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.Semantic proximity Read ↗

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