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Article

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.

Nature genetics - 1 Sept 2006

Maller Julian, George Sarah, Purcell Shaun, Fagerness Jes, Altshuler David, Daly Mark J, Seddon Johanna M

Abstract excerpt

Age-related macular degeneration (AMD) is a common, late-onset disease with seemingly typical complexity: recurrence ratios for siblings of an affected individual are three- to sixfold higher than in the general population, and family-based analysis has resulted in only modestly significant evidence for linkage. In a case-control study drawn from a US-based population of European descent, we have identified a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16936732
DOI: 10.1038/ng1873

Genes

CFH

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Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.PMID 16936732Read ↗

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A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.Semantic proximity Read ↗

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.Semantic proximity Read ↗

Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration.Semantic proximity Read ↗

A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration.Semantic proximity Read ↗

Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype.Semantic proximity Read ↗

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