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Article

Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.

Clinical and experimental immunology - 1 Jan 2008

de Córdoba S Rodríguez, de Jorge E Goicoechea

Abstract excerpt

Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (CFH) with atypical haemolytic uraemic syndrome (aHUS), age-related macular degeneration (AMD) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glomerulonephritis, Membranoproliferative

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Source

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Identifiers

PMID: 18081690
DOI: 10.1111/j.1365-2249.2007.03552.x
PMCID: PMC2276932

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.PMID 18081690Read ↗

The spectrum of phenotypes caused by variants in the CFH gene.Semantic proximity Read ↗

Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants.Semantic proximity Read ↗

Factor H genotype-phenotype correlations: lessons from aHUS, MPGN II, and AMD.Semantic proximity Read ↗

The human complement factor H: functional roles, genetic variations and disease associations.Semantic proximity Read ↗

Complement factor H related proteins (CFHRs)Semantic proximity Read ↗

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein FamilySemantic proximity Read ↗

Genetic deficiency of complement factor H in a patient with age-related macular degeneration and membranoproliferative glomerulonephritis.Semantic proximity Read ↗

Complement factor H and the hemolytic uremic syndromeSemantic proximity Read ↗

Comprehensive Analysis of Complement Genes in Patients with Atypical Hemolytic Uremic SyndromeSemantic proximity Read ↗

The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models.Semantic proximity Read ↗

A rare variant in CFH directly links age-related macular degeneration with rare glomerular nephropathies.Semantic proximity Read ↗

Complement Dysregulation and Disease: Insights from Contemporary Genetics.Semantic proximity Read ↗

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