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Article

Complement factor H polymorphisms, renal phenotypes and age-related macular degeneration: the Blue Mountains Eye Study.

Genes and immunity - 1 Apr 2008

Xing C, Sivakumaran T A, Wang J J, Rochtchina E, Joshi T, Smith W, Mitchell P, Iyengar S K

Abstract excerpt

Complement factor H (CFH) is a key regulator of the alternative pathway of complement and its mutations have been associated with membranoproliferative glomerulonephritis type II, atypical hemolytic uremic syndrome and age-related macular degeneration (AMD), suggesting that alternative pathway dysregulation is a common pathogenetic feature of these ocular and renal conditions. In this study we tested the...

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Identifiers

PMID: 18340363
DOI: 10.1038/gene.2008.10

Genes

CFH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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