Article
Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2007
Krüger Imme, Vollmer Marion, Simmons David G, Simmons David, Elsässer Hans-Peter, Philipsen Sjaak, Suske Guntram
Abstract excerpt
The ubiquitously expressed zinc finger transcription factors Sp1 and Sp3 play critical roles in embryonic development. Sp1 knockout mice die around embryonic day 10.5. Mice lacking Sp3 are postnatal lethal. Mice heterozygous for either Sp1 or Sp3 are apparently normal, although slightly smaller. Here, we show that compound heterozygosity of Sp1 and Sp3 results in embryonic lethality accompanied by a spectrum of...
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