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Article

Transcription factor Sp3 is essential for post-natal survival and late tooth development.

The EMBO journal - 15 Feb 2000

Bouwman P, Göllner H, Elsässer H P, Eckhoff G, Karis A, Grosveld F, Philipsen S, Suske G

Abstract excerpt

Sp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination. Sp3-deficient embryos are growth retarded and invariably die at birth of respiratory failure. The cause for the observed breathing defect remains obscure since only minor morphological alterations were observed in the lung, and surfactant protein...

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Identifiers

PMID: 10675334
DOI: 10.1093/emboj/19.4.655
PMCID: PMC305603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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