Article
Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 2001
Göllner H, Bouwman P, Mangold M, Karis A, Braun H, Rohner I, Del Rey A, Besedovsky H O, Meinhardt A, van den Broek M, Cutforth T, Grosveld F, Philipsen S, Suske G
Abstract excerpt
BACKGROUND: Sp4 is a zinc finger transcription factor which is closely related to Sp1 and Sp3. All three proteins recognize the same DNA elements and can act as transcriptional activators through glutamine-rich activation domains. Unlike Sp1 and Sp3, which are ubiquitous proteins, Sp4 is highly abundant in the central nervous system, but also detectable in many other tissues. RESULTS: We have disrupted the mouse...
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