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Article

Heart defects and embryonic lethality in Asb2 knock out mice correlate with placental defects.

Cells & development - 1 Mar 2021

Park Seul Gi, Kim Eun-Kyoung, Nam Ki-Hoan, Lee Jong Geol, Baek In-Jeoung, Lee Beom Jun, Nam Sang-Yoon

Abstract excerpt

Asb2, ankyrin repeat, and SOCS box protein 2 form an E3 ubiquitin ligase complex. Asb2 ubiquitin ligase activity drives the degradation of filamins, which have essential functions in humans. The placenta is a temporary organ that forms during pregnancy, and normal placentation is important for survival and growth of the fetus. Recent studies have shown that approximately 25-30% of knockout (KO) mice have...

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Share to Crosses, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Suppressor of Cytokine Signaling Proteins

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Identifiers

PMID: 33993984
DOI: 10.1016/j.cdev.2021.203663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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