Article

Conserved Roles of Sp1 in Zebrafish Development and Early Organogenesis

2026-01-13

Abstract excerpt

Transcription factors (TFs) function in combinatorial networks to orchestrate gene expression during development and disease. Yet, the mechanisms underlying their context-specific regulatory roles remain poorly understood. Here, we investigate Specificity Protein 1 (Sp1), the first sequence-specific transcription factor identified and a key regulator of TATA-less gene promoters as a model to elucidate conserved an...

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Literature Corpus work: bc829ebb-6bc5-5e14-b475-5f16c61b88aa
DOI: 10.64898/2026.01.12.699150

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