Article
An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension.
Human molecular genetics - 15 Jul 2007
Wen Gen, Wessel Jennifer, Zhou Weidong, Ehret Georg B, Rao Fangwen, Stridsberg Mats, Mahata Sushil K, Gent Peter M, Das Madhusudan, Cooper Richard S, Chakravarti Aravinda, Zhou Huilin, Schork Nicholas J, O'connor Daniel T, Hamilton Bruce A
Abstract excerpt
Granins regulate secretory vesicle formation in neuroendocrine cells and granin-derived peptides are co-released with neurotransmitters as modulatory signals at sympathetic sites. We report evidence for association between a regulatory polymorphism in Secretogranin II (SCG2) and hypertension in African-American subjects. The minor allele is ancestral in the human lineage and is associated with disease risk in two...
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